KRT80 Antibody (C-term)

Primary Antibodies; Signal Transduction

Keratins are intermediate filament proteins responsiblefor the structural integrity of epithelial cells and are subdividedinto epithelial keratins and hair keratins. This gene's expressionprofile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type IIhair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages ofdifferentiation but then dispersing throughout the cytoplasm interminally differentiating cells. The type II keratins areclustered in a region of chromosome 12q13. Two transcript variantsencoding two different fully functional isoforms have been foundfor this gene.

RB28277

Affinity Purified Rabbit Polyclonal Antibody (Pab)

50525

404-432

WB: 1:1000