PAK6 Antibody (Center)

Synthetic Peptide

This gene encodes a member of the p21-activated kinase
(PAK) family. The proteins of this family are Rac/Cdc42-associated
Ste20-like Ser/Thr protein kinases, characterized by a highly
conserved amino-terminal Cdc42/Rac interactive binding (CRIB)
domain and a carboxyl-terminal kinase domain. PAK kinases are
implicated in the regulation of a number of cellular processes,
including cytoskeleton rearrangement, apoptosis and the MAP kinase
signaling pathway. The protein encoded by this gene was found to
interact with androgen receptor (AR), which is a steroid
hormone-dependent transcription factor that is important for male
sexual differentiation and development. This gene was found to be
highly expressed in testis and prostate tissues and the encoded
protein was shown to cotranslocate into the nucleus with AR in
response to androgen. Alternatively spliced transcript variants
encoding the same protein have been found for this gene. [provided
by RefSeq].

Polyclonal

106821730; 56924

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Confocal immunofluorescent analysis of PAK6 Antibody (Center)(Cat#AP12164c) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

1:10~50

WB

PAK6 Antibody (Center) (Cat. #AP12164c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PAK6 antibody detected the PAK6 protein (arrow).

1:1000

IHC-P

NP_001122100.1

74869

HUMAN

NP_001122100.1; NP_001122101.1; NP_001263646.1; NP_001263647.1; NP_064553.1