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SENP1 Antibody (N-term)

SENP1 Antibody (N-term)

ArtNr	ABC-AP1230a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SENP1, Sentrin-specific protease 1, Sentrin/SUMO-specific protease SENP1
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Primary Accession	Q9P0U3
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.
Bio References	Gong, L., et al., J. Biol. Chem. 275(5):3355-3359 (2000). Bailey, D., et al., J. Gen. Virol. 83 (Pt 12), 2951-2964 (2002).
Clonality	Polyclonal
Clone/Animal Names	RB0647
Gene ID	29843
Gene Name	SENP1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of SENP1 polyclonal antibody (Cat. #AP1230)in whole HL60 cell lysate: SENP1 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	Formalin-fixed and paraffin-embedded human Thymus tissue reacted with SENP1 Antibody (N-term)(Cat.#AP1230a), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:50~100
Isotype	Rabbit Ig
Calculated MW	73481
Antigen Region	28-59
Antigen Source	HUMAN
Target/Specificity	This SENP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human SENP1.
NCBI Accession	NP_001254523.1; NP_001254524.1

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Menge: 80 ul

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