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MCM6 Antibody (N-term)

MCM6 Antibody (N-term)

ArtNr	ABC-AP14743a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MCM6, DNA replication licensing factor MCM6, p105MCM
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Primary Accession	Q14566
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
Bio References	Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press : Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1341-1348(2010) Wei, Z., et al. J. Biol. Chem. 285(17):12469-12473(2010) Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) : Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Clonality	Polyclonal
Clone/Animal Names	RB34942
Gene ID	4175
Gene Name	MCM6
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	MCM6 Antibody (N-term) (Cat. #AP14743a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MCM6 antibody detected the MCM6 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	MCM6 Antibody (N-term) (AP14743a)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MCM6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q2KIZ8; NP_005906.2
Predicted	B
Isotype	Rabbit Ig
Calculated MW	92889
Antigen Region	80-109
Antigen Source	HUMAN
Target/Specificity	This MCM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the N-terminal region of human MCM6.
NCBI Accession	NP_005906.2

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