COIL Antibody (Center)

NP_004636.1

The protein encoded by this gene is an integral component
of Cajal bodies (also called coiled bodies). Cajal bodies are
nuclear suborganelles of varying number and composition that are
involved in the post-transcriptional modification of small nuclear
and small nucleolar RNAs. The N-terminus of the coilin protein
directs its self-oligomerization while the C-terminus influences
the number of nuclear bodies assembled per cell. Differential
methylation and phosphorylation of coilin likely influences its
localization among nuclear bodies and the composition and assembly
of Cajal bodies. This gene has pseudogenes on chromosome 4 and
chromosome 14.

8161

H

157-186

This COIL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the Central region of human COIL.