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Kremen Antibody (N-term)

Kremen Antibody (N-term)

ArtNr	ABC-AP1527a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	KREMEN1, Kringle-containing protein marking the eye and the nose, KREMEN, KRM1, Kremen protein 1, Dickkopf receptor, Kringle domain-containing transmembrane protein 1
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Primary Accession	Q96MU8
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	Kremen is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains.
Bio References	Mao, B., et al., Nature 417(6889):664-667 (2002). Nakamura, T., et al., Biochim. Biophys. Acta 1518 (1-2), 63-72 (2001).
Clonality	Polyclonal
Clone/Animal Names	RB2551
Gene ID	83999
Gene Name	KREMEN1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of Kremen (arrow) using Kremen Antibody (N-term) (Cat.#AP1527a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Kremen gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Kremen (DKK5) Antibody (R21) (Cat. #AP1527a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Kremen (DKK5) antibody detected the Kremen (DKK5) protein (arrow).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 3	IHC-P
Dilution image 3	1:50~100
Other Accession	NP_114434
Isotype	Rabbit Ig
Calculated MW	51744
Antigen Region	6-37
Antigen Source	HUMAN
Target/Specificity	This Kremen antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-37 amino acids from the N-terminal region of human Kremen.
NCBI Accession	NP_001034659.2; NP_114434.3

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Menge: 400 ul

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