TTK Antibody (N-term)

Q4R945; NP_003309.2

This gene encodes a dual specificity protein kinase with
the ability to phosphorylate tyrosine, serine and threonine.
Associated with cell proliferation, this protein is essential for
chromosome alignment at the centromere during mitosis and is
required for centrosome duplication. It has been found to be a
critical mitotic checkpoint protein for accurate segregation of
chromosomes during mitosis. Tumorigenesis may occur when this
protein fails to degrade and produces excess centrosomes resulting
in aberrant mitotic spindles. Alternative splicing results in
multiple transcript variants.

7272

H

97072

HUMAN

NP_001160163.1; NP_003309.2