HLA-DPA1 Antibody (C-term)

Synthetic Peptide

HLA-DPA1 belongs to the HLA class II alpha chain
paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta (DPB) chain, both anchored in the
membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II
molecules are expressed in antigen presenting cells (APC: B
lymphocytes, dendritic cells, macrophages). The alpha chain is
approximately 33-35 kDa and its gene contains 5 exons. Exon one
encodes the leader peptide, exons 2 and 3 encode the two
extracellular domains, exon 4 encodes the transmembrane domain and
the cytoplasmic tail. Within the DP molecule both the alpha chain
and the beta chain contain the polymorphisms specifying the peptide
binding specificities, resulting in up to 4 different molecules.

Polyclonal

3113

Affinity Purified Rabbit Polyclonal Antibody (Pab)

HLA-DPA1 Antibody (C-term) (Cat. #AP17796b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HLA-DPA1 antibody detected the HLA-DPA1 protein (arrow).

1:1000

Rabbit Ig

231-259

This HLA-DPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the C-terminal region of human HLA-DPA1.