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TFEB Antibody (Center)

TFEB Antibody (Center)

ArtNr	ABC-AP18994c-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TFEB, BHLHE35, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35
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Primary Accession	P19484
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Bio References	Martignoni, G., et al. Mod. Pathol. 22(8):1016-1022(2009) Sardiello, M., et al. Science 325(5939):473-477(2009) Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008) Pecciarini, L., et al. Genes Chromosomes Cancer 46(5):419-426(2007) Argani, P., et al. Am. J. Surg. Pathol. 29(2):230-240(2005)
Clonality	Polyclonal
Clone/Animal Names	RB39331
Gene ID	7942
Gene Name	TFEB {ECO:0000303\|PubMed:2115126, ECO:0000312\|HGNC:HGNC:11753}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	TFEB Antibody (Center) (Cat. #AP18994c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TFEB antibody detected the TFEB protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Other Accession	Q9R210; NP_009093.1
Predicted	M
Isotype	Rabbit Ig
Calculated MW	52865
Antigen Region	271-300
Antigen Source	HUMAN
Target/Specificity	This TFEB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human TFEB.
NCBI Accession	NP_001161299.2; NP_001258872.1; NP_001258873.1; NP_001258874.1; NP_009093.1

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Menge: 80 ul

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