« Zurück
Startseite /
RUVBL1 (TIP49) Antibody (Center)

RUVBL1 (TIP49) Antibody (Center)

ArtNr	ABC-AP1922a-ev-80ul
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	Western Blot, Flow cytometry, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	RuvB-like 1, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, INO80 complex subunit H, Nuclear matrix protein 238, NMP 238, Pontin 52, TIP49a, TIP60-associated protein 54-al
Lieferbar
Primary Accession	Q9Y265
Other Accession	P60123; P60122; Q8AWW7
Antigen Type	Synthetic Peptide
Bio Background	RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1 -CTNNB1 complex. High levels of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis.
Bio References	Feng, Y., et al., Cancer Res. 63(24):8726-8734 (2003). Hawley, S.B., et al., J. Biol. Chem. 276(1):179-186 (2001). Ikura, T., et al., Cell 102(4):463-473 (2000). Salzer, U., et al., Biochim. Biophys. Acta 1446(3):365-370 (1999). Makino, Y., et al., Biochem. Biophys. Res. Commun. 245(3):819-823 (1998).
Gene ID	8607
Gene Name	RUVBL1
Reactivity	H
Predicted	Zf, M, Rat
Calculated MW	50228
Antigen Region	247-280
Antigen Source	HUMAN
Target/Specificity	This RUVBL1 (TIP49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-280 amino acids from the Central region of human RUVBL1 (TIP49).
NCBI Accession	NP_003698.1

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

ABC-AP1922a-ev-80ul-datasheet.pdf

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 80 ul

nicht lieferbar