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Phospho-SMAD3(S208) Antibody

Phospho-SMAD3(S208) Antibody

ArtNr	ABC-AP3249a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Antibodies Immunofluorescence Primary Antibodies By Organ Colorectal Cancer Dot Blot
Typ	Antibody Polyclonal
Applikationen	IF, Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Imoto, S., et al., FEBS Lett. 579(13):2853-2862 (2005). 2.Dubrovska, A., et al., Oncogene 24(14):2289-2297 (2005). 3.Furumatsu, T., et al., J. Biol. Chem. 280(9):8343-8350 (2005). 4.Kobayashi, T., et al., Biochem. Biophys. Res. Commun. 327(2):393-398 (2005). 5.Kamaraju, A.K., et al., J. Biol. Chem. 280(2):1024-1036 (2005). References for HeLa cell line: 1. Scherer WF, Syverton JT, Gey GO (May 1953). "Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix". J. Exp. Med. 97 (5): 695–710. [PubMed:13052828]. 2. Macville M, Schröck E, Padilla-Nash H, Keck C, Ghadimi BM, Zimonjic D, Popescu N, Ried T (January 1999). "Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping". Cancer Res. 59 (1): 141–50. [PubMed: 9892199]. 3. Rahbari R, Sheahan T, Modes V, Collier P, Macfarlane C, Badge RM (April 2009). "A novel L1 retrotransposon marker for HeLa cell line identification". BioTechniques 46 (4): 277–84. [PubMed: 19450234]. 4. Capes-Davis A, Theodosopoulos G, Atkin I, Drexler HG, Kohara A, MacLeod RA, Masters JR, Nakamura Y, Reid YA, Reddel RR, Freshney RI (July 2010). "Check your cultures! A list of cross-contaminated or misidentified cell lines". Int. J. Cancer 127 (1): 1–8. [PubMed:20143388].
NCBI	NP_001138574.1,NP_001138575.1,NP_001138576.1,NP_005893.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mothers against decapentaplegic homolog 3,MAD homolog 3,Mad3,Mothers against DPP homolog 3,hMAD-3,JV15-2,SMAD family member 3,SMAD 3,Smad3,hSMAD3,SMAD3,MADH3
Similar products	SMAD3, Smad3, MADH3, Mothers against decapentaplegic homolog 3, JV15-2, SMAD family member 3, Mad3, SMAD 3, Mothers against DPP homolog 3, hSMAD3, hMAD-3, MAD homolog 3
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Developmental Biology; Metabolism; Neuroscience; Signal Transduction; Phospho Antibodies; SARS-Human interactions; SARS-Human interaction partners
Manufacturer - Targets	This SMAD3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S208 of human SMAD3.
Bio Background	SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 8% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB31592, RB31594
Gene Name	SMAD3
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	C, M, Pig, Rat
Calculated Molecular Weight	48081
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:200 IF: 1:10~50 DB: 1:500
Antigen Type	Synthetic Peptide

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Menge: 400 ul

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