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MMP24 Antibody (Center)

MMP24 Antibody (Center)

ArtNr	ABC-AP6205a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MMP24, MT5MMP, Matrix metalloproteinase-24, Membrane-type matrix metalloproteinase 5, Membrane-type-5 matrix metalloproteinase, Processed matrix metalloproteinase-24, 3424-, MMP-24, MTMMP5, MT5-MMP, MT-MMP 5
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Primary Accession	Q9Y5R2
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).
Bio References	Jung, M., et al., Prostate 55(2):89-98 (2003). Kajita, M., et al., FEBS Lett. 457(3):353-356 (1999). Llano, E., et al., Cancer Res. 59(11):2570-2576 (1999). Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999). Kinoh, H., et al., Cytogenet. Cell Genet. 87 (1-2), 97-98 (1999).
Clonality	Polyclonal
Clone/Animal Names	RB2041/2042
Gene ID	10893
Gene Name	MMP24
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of MMP24 Antibody (Center) (Cat.#AP6205a) in HL60 cell line lysates (35ug/lane). MMP24 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	Q99PW6; Q9R0S2; NP_006681
Predicted	M, Rat
Isotype	Rabbit Ig
Calculated MW	73231
Antigen Region	396-425
Antigen Source	HUMAN
Target/Specificity	This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the Central region of human MMP24.
NCBI Accession	NP_006681.1

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