Vergleich

IDH1 Antibody (N-term)

ArtNr ABC-AP7454A-ev-80ul
Hersteller Abcepta
Menge 80 ul
Kategorie
Typ Antibody Polyclonal
Applikationen Immunofluorescence, Western Blot, Flow cytometry, Immunohistochemistry
Specific against other
Host Rabbit
Isotype Ig
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, IDH1, PICD
Lieferbar
Primary Accession
O75874
Other Accession
P41562; O88844; Q9XSG3; Q6XUZ5
Antigen Type
Synthetic Peptide
Bio Background
IDH1 belongs to two distinct subclasses. The protein is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. This protein contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Bio References
Geisbrecht B.V., Gould S.J.J. Biol. Chem. 274:30527-30533(1999)
Xu X., Zhao J., Xu Z.J. Biol. Chem. 279:33946-33957(2004)
Bleeker F.E., Lamba S.Hum. Mutat. 30:7-11(2009)
Gene ID
3417
Gene Name
IDH1
Reactivity
H, M
Predicted
B, Rat, Sh
Calculated MW
46659
Antigen Region
63-90
Antigen Source
HUMAN
Target/Specificity
This IDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human IDH1.
NCBI Accession
NP_001269315.1; NP_001269316.1; NP_005887.2

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