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TMEM173 Antibody (C-term)

ArtNr ABC-AP9747b
Hersteller Abcepta
Menge 400 ul
Kategorie
Typ Antibody Primary
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen WB, FC
Specific against other
Host Rabbit
Isotype Ig
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products MITA, TMEM173, ERIS, STING, Endoplasmic reticulum interferon stimulator, hMITA, hSTING, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173
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Primary Accession
Q86WV6
Antigen Type
Synthetic Peptide
Application
WB, FC
Bio Background
Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Bio References
Sun, W., et al. Proc. Natl. Acad. Sci. U.S.A. 106(21):8653-8658(2009)
Zhong, B., et al. Immunity 30(3):397-407(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009)
Clonality
Polyclonal
Clone/Animal Names
RB24462
Gene ID
340061
Gene Name
STING
Subtitle
Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity
H
Legend image 1
Western blot analysis of lysate from U-937 cell line, using TMEM173 Antibody (C-term)(Cat. #AP9747b). AP9747b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
Type image 1
WB
Dilution image 1
1:1000
Legend image 2
TMEM173 Antibody (C-term) (Cat. #AP9747b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2
FC
Dilution image 2
1:10~50
Isotype
Rabbit Ig
Calculated MW
42193
Antigen Region
311-340
Antigen Source
HUMAN
Target/Specificity
This TMEM173 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human TMEM173.
NCBI Accession
NP_938023.1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 400 ul
Lieferbar: In stock
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