IL-1RAcP Antibody

ArtNr	ABC-ASC10066
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IF, ICC, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	IL-1RAcP, C3orf13, IL1R3, IL-1RAcP Antibody: IL1R3, Interleukin-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1 receptor accessory protein, interleukin 1 receptor accessory protein
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Primary Accession	Q9NPH3
Application	WB, IF, ICC, E
Bio Background	IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κ B inducing kinae (NIK) and of NF-κ B, recruits to the IL-1R complex through IL-1RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
Bio References	Greenfeder SA, Nunes P, Kwee L, et al. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 1995; 270:13757-65. Huang J, Gao X, Li S, et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997; 94:12829-32. Wesche H, Korherr C, Kracht M, et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J. Biol. Chem. 1997; 272:7727-31. Hofmeister R, Wiegmann K, Korherr C, et al. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. J. Biol. Chem. 1997; 272:27730-6.
Clonality	Polyclonal
Gene ID	3556
Gene Name	IL1RAP
Reactivity	H
Legend image 1	Immunofluorescence of ORAI3 in 293 cells with ORAI3 antibody at 5 µg/ml.
Type image 1	IF
Legend image 2	Immunofluorescence of ZIPK in Jurkat cells with ZIPK antibody at 5 µg/ml.
Type image 2	IF
Other Accession	NP_001161401; 3556
Isotype	IgG
Calculated MW	65418
Antigen Source	Homo sapiens
Target/Specificity	IL-1RAcP antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IL-1RAcP. The immunogen is located within the last 50 amino acids of IL-1RAcP.
Purification	IL-1RAcP Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	IL-1RAcP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	IL-1RAcP antibody can be used for detection of IL-1RAcP by Western blot at 1 μ g/mL. Antibody can also be used for Immunohistochemistry starting at 2 μ g/mL. For immunofluorescence start at 5 μ g/mL.
Positive Control	HeLa Cell Lysate;
Buffer	IL-1RAcP Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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