ASC Antibody

ArtNr	ABC-ASC10110
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, ICC, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ASC, TMS1, TMS, CARD5, Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, TMS-1, hASC, PYD and CARD domain containing, ASC Antibody: ASC
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Primary Accession	Q9ULZ3
Application	WB, ICC, E
Bio Background	ASC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3, 4). Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
Bio References	Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, Hidaka E, Katsuyama T, Higuchi T, Sagara J. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1999; 274(48):33835-8. Masumoto J, Taniguchi S, Nakayama K, Ayukawa K, Sagara J. Murine Ortholog of ASC, a CARD-Containing Protein, Self-Associates and Exhibits Restricted Distribution in Developing Mouse Embryos. Exp Cell Res. 2001; 262(2):128-133. Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST , Vertino PM. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res. 2000; 60(22):6236-42. McConnell BB, Vertino PM. Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. Cancer Res. 2000; 60(22):6243-7. (WD0102)
Clonality	Polyclonal
Gene ID	29108
Gene Name	PYCARD
Reactivity	H
Legend image 1	Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide with ASC antibody at 1 µg /ml.
Type image 1	WB
Legend image 2	Immunocytochemistry of ASC in HL60 cells with ASC antibody at 5 µg/mL.
Type image 2	ICC
Other Accession	BAA87339; 10801602
Isotype	IgG
Calculated MW	21627
Antigen Source	Homo sapiens
Target/Specificity	PYCARD;
Purification	ASC Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	ASC antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	ASC antibody can be used for detection of ASC/TMS1 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL.
Positive Control	HL60 Cell Lysate;
Buffer	ASC Antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC10110-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 02.10.2025

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