TSLP Antibody

Q969D9

TSLP Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.

Polyclonal

TSLP

Western blot analysis of TSLP in A-20 cell lysate with TSLP antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.

Immunohistochemistry of TSLP in mouse brain tissue with TSLP antibody at 2.5 µg/mL.

Immunofluorescence of TSLP in Mouse Brain tissue with TSLP antibody at 20 µg/mL.

NP_067342; 85480

18141

TSLP antibody was raised against a 20 amino acid synthetic peptide from near the center of mouse TSLP.

The immunogen is located within amino acids 70 - 120 of TSLP.

TSLP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

TSLP antibody can be used for detection of TSLP by Western blot at 0.5 - 2 μ g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ g/mL. For immunofluorescence start at 20 μ g/mL.

TSLP Antibody is supplied in PBS containing 0.02% sodium azide.