NPAS3 Antibody

Q8IXF0

NPAS3 Antibody: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.

Polyclonal

NPAS3

Western blot analysis of NPAS3 in rat brain tissue lysate with NPAS3 antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.

Immunohistochemistry of NPAS3 in human brain tissue with NPAS3 antibody at 5 µg/mL.

Immunofluorescence of NPAS3 in Human Brain cells with NPAS3 antibody at 20 µg/mL.

Q8IXF0; 38604888

100805

NPAS3;

NPAS3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.

NPAS3 Antibody is supplied in PBS containing 0.02% sodium azide.