LIMP2 Antibody

Q14108

LIMP2 Antibody: The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind beta-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted beta-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor.

Polyclonal

SCARB2

Western blot analysis of LIMP2 in mouse liver tissue lysate with LIMP2 antibody at 1 µg/mL in (A) the absence and (B) presence of blocking peptide.

Immunohistochemistry of LIMP2 in human skeletal muscle tissue with LIMP2 antibody at 2.5 µg/mL.

Immunofluorescence of LIMP2 in Human Skeletal Muscle tissue with LIMP2 antibody at 20 µg/mL.

AAH21892; 18257312

54290

SCARB2;

LIMP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

LIMP2 antibody can be used for detection of LIMP2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.

LIMP2 Antibody is supplied in PBS containing 0.02% sodium azide.