RKHD3 Antibody

Q6ZN04

RKHD3 Antibody: Rkhd3, also known as MEX3B is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd3 is thought to act as a mechanism to fine-tune mRNA regulation in early Xenopus development, and with Rkhd4, but not Rkhd1, will co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Polyclonal

MEX3B

Western blot analysis of RKHD3 in mouse skeletal muscle tissue lysate with RKHD3 antibody at 1 µg/mL.

Immunofluorescence of RKHD3 in mouse skeletal muscle cells with RKHD3 antibody at 20 µg/mL.

NP_780575; 47716512

58832

MEX3B; This antibody is specific for RKHD3 and will not recognize the other RKHD3 family of proteins.

RKHD3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

RKHD3 antibody can be used for detection of EPAC1 by Western blot at 1 µg/mL. Antibody can also be used for immunofluorescence starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.

RKHD3 Antibody is supplied in PBS containing 0.02% sodium azide.