TMEM107 Antibody

ArtNr	ABC-ASC11701
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Primary Accession	Q6UX40
Application	WB, IHC-P, IF, E
Bio Background	Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1). It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1, 2). TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1, 3). TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3).
Bio References	Christopher KJ, Wang B, Kong Y, et al. Forward genetics uncovers transmembrane protein 107 as a novel factor required for ciliogenesis and sonic hedgehog signaling. Dev. Biol. 2012; 368:382-92. Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70. Ho KS and Scott MP. Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr. Opin. Neurobiol. 2002; 12:57-63.
Clonality	Polyclonal
Gene ID	84314
Gene Name	TMEM107 (HGNC:28128)
Reactivity	H
Legend image 1	Western blot analysis of TMEM107 in THP-1 cell lysate with TMEM107 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Type image 1	WB
Legend image 2	Immunohistochemistry of TMEM107 in human lymph node tissue with TMEM107 antibody at 5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of TMEM107 in human lymph node tissue with TMEM107 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_115730; 34101276
Isotype	IgG
Calculated MW	15503
Antigen Source	homo sapiens
Target/Specificity	TMEM107; TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.
Purification	TMEM107 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	TMEM107antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form	Liquid
Application Notes	TMEM107 antibody can be used for detection of TMEM107 by Western blot at 1 - 2 µg/ml.
Positive Control	;
Buffer	TMEM107 Antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC11701-datasheet.pdf

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Menge: 100 ug

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