SRPK1 Antibody

ArtNr	ABC-ASC11965
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Primary Accession	Q96SB4
Application	WB, IHC, E
Bio Background	SRPK1 and SRPK2, two Arginine/serine-rich (SR) protein-specific kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells (1). They are highly specific for the phosphorylation of these RS proteins, and highly expressed in testis (1, 2). SRPK1 plays a role in the condensation of sperm chromatin and controls the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis (3, 4).
Bio References	Wang HY, Arden KC, Bermingham JR Jr, et al. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Genomics 1999; 57:310-5. Daub H, Blencke S, Habenberger P, et al. Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. J. Virol. 2002; 76:8124-37. Zhong XY, Ding JH, Adams JA, et al. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009; 23:482-95. Mavrou A, Brakspear K, Hamdollah-Zadeh M, et al. Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer. Oncogene 2014 Nov 10. doi: 10.1038/onc.2014.360.
Clonality	Polyclonal
Gene ID	6732
Gene Name	SRPK1 {ECO:0000312\|EMBL:CAC39299.1}
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of SRPK1 in mouse heart tissue lysate with SRPK1 antibody at 1 µg/ml.
Type image 1	WB
Legend image 2	Immunohistochemistry of SRPK1 in human testis tissue with SRPK1 antibody at 5 µg/ml.
Type image 2	IHC
Other Accession	NP_003128; 47419936
Isotype	IgG
Calculated MW	74325
Antigen Source	homo sapiens
Target/Specificity	SRPK1; SRPK1 antibody is human, mouse and rat reactive. Multiple isoforms of SRPK1 are known to exist; this antibody will detect all except isoforms b and e. SRPK1 antibody is predicted to not cross-react with SRPK2.
Purification	SRPK1 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	SRPK1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form	Liquid
Application Notes	SRPK1 antibody can be used for the detection of SRPK1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry at 5 µg/ml.
Positive Control	Mouse Liver Tissue Lysate;
Buffer	SRPK1 Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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