ErbB2IP

ArtNr	ABC-AT1935a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, ELISA
Clon	10G1
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	LAP2, ERBB2IP, ERBIN, Erbin, Protein LAP2, Densin-180-like protein, Erbb2-interacting protein, KIAA1225
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Primary Accession	Q96RT1
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.
Bio References	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Densin-180: revised membrane topology, domain structure and phosphorylation status. Thalhammer A, et al. J Neurochem, 2009 Apr. PMID 19187442.Biochemical studies and molecular dynamics simulations of Smad3-Erbin interaction identify a non-classical Erbin PDZ binding. D?liot N, et al. Biochem Biophys Res Commun, 2009 Jan 16. PMID 19013433.The PDZ protein erbin modulates beta-catenin-dependent transcription. Ress A, et al. Eur Surg Res, 2008. PMID 18667832.Palmitoylation of ERBIN is required for its plasma membrane localization. Izawa I, et al. Genes Cells, 2008 Jul. PMID 18498353.
Clonality	monoclonal
Gene ID	55914
Gene Name	ERBIN {ECO:0000303\|PubMed:10878805}
Subtitle	Mouse monoclonal antibody raised against a partial recombinant ERBB2IP.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Detection limit for recombinant GST tagged ERBB2IP is approximately 0.03ng/ml as a capture antibody.
Type image 2	E
Other Accession	NM_018695
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	ERBB2IP (NP_061165, 1272 a.a. ~ 1371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001006600.1; NP_001240626.1; NP_001240627.1; NP_001240628.1; NP_001240630.1; NP_061165.1
	Clone: 10G1
Org Accession	NP_061165
Gene Description	erbb2 interacting protein
Gene Summary	This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. [provided by RefSeq

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Menge: 100 ug

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