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MCM3 Antibody (monoclonal) (M03)

MCM3 Antibody (monoclonal) (M03)

ArtNr	ABC-AT2820a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, ELISA
Clon	30
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MCM3, p102, DNA replication licensing factor MCM3, P1-MCM3, DNA polymerase alpha holoenzyme-associated protein P1, RLF subunit beta
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Primary Accession	P25205
Antigen Type	Recombinant Protein
Application	WB, IF, E
Bio Background	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Bio References	Human cytomegalovirus IE86 protein binds to cellular Mcm3 protein but does not inhibit its binding to the Epstein-Barr virus oriP in U373MG-p220.2 cells. Song YJ, et al. Acta Virol, 2010. PMID 20545442.Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.Analysis of interaction partners of H4 histone by a new proteomics approach. Saade E, et al. Proteomics, 2009 Nov. PMID 19862764.Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. Lee YS, et al. Exp Mol Pathol, 2010 Feb. PMID 19818763.Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex. Lin DI, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18524952.
Clonality	Monoclonal
Gene ID	4172
Gene Name	MCM3
Subtitle	Mouse monoclonal antibody raised against a partial recombinant MCM3.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to MCM3 on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	MCM3 monoclonal antibody (M03), clone 3E1 Western Blot analysis of MCM3 expression in HeLa ( (Cat # AT2820a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	MCM3 monoclonal antibody (M03), clone 3E1. Western Blot analysis of MCM3 expression in Hela S3 NE ( (Cat # AT2820a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Detection limit for recombinant GST tagged MCM3 is approximately 0.1ng/ml as a capture antibody.
Type image 5	E
Other Accession	NM_002388
Isotype	IgG2b Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	MCM3 (NP_002379, 699 a.a. ~ 808 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001257401.1; NP_002379.3
	Clone: 30
Org Accession	NP_002379
Gene Description	minichromosome maintenance complex component 3
Gene Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq

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Menge: 100 ug

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