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MYOC Antibody (monoclonal) (M01)

MYOC Antibody (monoclonal) (M01)

ArtNr	ABC-AT2961a
Hersteller	Abcepta
Menge	50 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IP, IHC, ELISA
Clon	4F8
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MYOC, N-terminal fragment, C-terminal fragment, GLC1A, TIGR, Myocilin, Myocilin 55 kDa subunit, Trabecular meshwork-induced glucocorticoid response protein, Myocilin 20 kDa N-terminal fragment, Myocilin 35 kDa N-terminal fragment
Lieferbar
Primary Accession	Q99972
Antigen Type	Recombinant Protein
Application	WB, IHC, IP, E
Bio Background	MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
Bio References	Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. McDonald KK, et al. J Hum Genet, 2010 Jul 29. PMID 20668460.Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma. Sohn S, et al. Br J Ophthalmol, 2010 May. PMID 20447966.[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg] Motushchuk AE, et al. Genetika, 2009 Dec. PMID 20198978.Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population. Wirtz MK, et al. Invest Ophthalmol Vis Sci, 2010 Jun. PMID 20107173.Variable clinical spectrum of the myocilin Gln368X mutation in a Dutch family with primary open angle glaucoma. Hogewind BF, et al. Curr Eye Res, 2010 Jan. PMID 20021252.
Clonality	Monoclonal
Gene ID	4653
Gene Name	MYOC
Subtitle	Mouse monoclonal antibody raised against a partial recombinant MYOC.
Reactivity	H
Legend image 1	Immunoprecipitation of MYOC transfected lysate using anti-MYOC monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with MYOC MaxPab rabbit polyclonal antibody.
Type image 1	IP
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western Blot analysis of MYOC expression in transfected 293T cell line by MYOC monoclonal antibody (M01), clone 4F8. Lane 1: MYOC transfected lysate(57 KDa). Lane 2: Non-transfected lysate.
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western blot analysis of MYOC over-expressed 293 cell line, cotransfected with MYOC Validated Chimera RNAi ( (Cat # AT2961a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Immunoperoxidase of monoclonal antibody to MYOC on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
Type image 5	IHC
Legend image 6	Detection limit for recombinant GST tagged MYOC is approximately 0.3ng/ml as a capture antibody.
Type image 6	E
Other Accession	BC029261
Isotype	IgG1 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	MYOC (AAH29261, 36 a.a. ~ 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_000252.1
	Clone: 4F8
Org Accession	AAH29261
Gene Description	myocilin, trabecular meshwork inducible glucocorticoid response
Gene Summary	MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq

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Menge: 50 ug

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