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PPARD Antibody (monoclonal) (M01)

ArtNr ABC-AT3394a
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen WB, ELISA
Clon 4E3-1B11
Specific against other
Host Mouse
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products PPAR-delta, PPARD, NR1C2, PPARB, Peroxisome proliferator-activated receptor delta, NUCI, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, NUC1
Lieferbar
Primary Accession
Q03181
Antigen Type
Recombinant Protein
Application
WB, E
Bio Background
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Bio References
1.PGC1{alpha} relationship with skeletal muscle palmitate oxidation is not present with obesity, despite maintained ained PGC1{alpha} and PGC1{beta} protein.Holloway GP, Perry CG, Thrush AB, Heigenhauser GJ, Dyck DJ, Bonen A, Spriet LL.Am J Physiol Endocrinol Metab. 2008 Jun; 294(6):E1060-9. Epub 2008 Mar 18.
Clonality
Monoclonal
Gene ID
5467
Gene Name
PPARD
Subtitle
Mouse monoclonal antibody raised against a full length recombinant PPARD.
Reactivity
H
Legend image 1
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (65.45 KDa) .
Type image 1
WB
Dilution image 1
1:500~1000
Legend image 2
PPARD monoclonal antibody (M01), clone 4E3-1B11 Western Blot analysis of PPARD expression in Jurkat ( (Cat # AT3394a )
Type image 2
WB
Dilution image 2
1:500~1000
Legend image 3
Detection limit for recombinant GST tagged PPARD is approximately 0.03ng/ml as a capture antibody.
Type image 3
E
Legend image 4
Proximity Ligation Analysis of protein-protein interactions between HDAC2 and PPARD HeLa cells were stained with anti-HDAC2 rabbit purified polyclonal 1:1200 and anti-PPARD mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Other Accession
BC002715
Isotype
IgG1 kappa
Antigen Source
Human: ~~ Positive
Target/Specificity
PPARD (AAH02715, 1 a.a. ~ 361 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession
NP_001165289.1; NP_001165290.1; NP_001165291.1; NP_006229.1; NP_803184.1
Clone: 4E3-1B11
Org Accession
AAH02715
Gene Description
peroxisome proliferator-activated receptor delta
Gene Summary
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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