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RNF12 Antibody (monoclonal) (M01)

RNF12 Antibody (monoclonal) (M01)

ArtNr	ABC-AT3658a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, IP, ELISA
Clon	1G10
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RLIM, RNF12, E3 ubiquitin-protein ligase RLIM, LIM domain-interacting RING finger protein, RING finger LIM domain-binding protein, RING finger protein 12, Renal carcinoma antigen NY-REN-43, 632-, R-LIM
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Primary Accession	Q9NVW2
Antigen Type	Recombinant Protein
Application	WB, IF, IP, E
Bio Background	The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Bio References	1.Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling.Zhou F, Drabsch Y, Dekker TJ, de Vinuesa AG, Li Y, Hawinkels LJ, Sheppard KA, Goumans MJ, Luwor RB, de Vries CJ, Mesker WE, Tollenaar RA, Devilee P, Lu CX, Zhu H, Zhang L, Dijke PTNat Commun. 2014 Mar 3; 5:3388. doi: 10.1038/ncomms4388.
Clonality	Monoclonal
Gene ID	51132
Gene Name	RLIM
Subtitle	Mouse monoclonal antibody raised against a partial recombinant RNF12.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to RNF12 on HeLa cell. [antibody concentration 30 ug/ml]
Type image 1	IF
Legend image 2	Immunoprecipitation of RNF12 transfected lysate using anti-RNF12 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with RNF12 MaxPab rabbit polyclonal antibody.
Type image 2	IP
Legend image 3	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (34.87 KDa) .
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	RNF12 monoclonal antibody (M01), clone 1G10. Western Blot analysis of RNF12 expression in Hela S3 NE.
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Western Blot analysis of RNF12 expression in transfected 293T cell line by RNF12 monoclonal antibody (M01), clone 1G10. Lane 1: RNF12 transfected lysate (Predicted MW: 68.5 KDa). Lane 2: Non-transfected lysate.
Type image 5	WB
Dilution image 5	1:500~1000
Legend image 6	Detection limit for recombinant GST tagged RNF12 is approximately 0.03ng/ml as a capture antibody.
Type image 6	E
Other Accession	NM_016120
Isotype	IgG2a Kappa
Target/Specificity	RNF12 (NP_057204, 1 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_057204.2; NP_899196.1
	Clone: 1G10
Org Accession	NP_057204
Concentration	0.4 mg/ml
Gene Description	ring finger protein 12
Gene Summary	The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq

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Menge: 100 ug

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