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TNFRSF10B Antibody (monoclonal) (M01)

TNFRSF10B Antibody (monoclonal) (M01)

ArtNr	ABC-AT4271a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IP, ELISA
Clon	2D6
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	DR5, TNFRSF10B, CD262, KILLER, TRICK2, TRAIL-R2, TRAILR2, ZTNFR9, TNF-related apoptosis-inducing ligand receptor 2, Death receptor 5, TRAIL receptor 2, Tumor necrosis factor receptor superfamily member 10B
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Primary Accession	O14763
Antigen Type	Recombinant Protein
Application	WB, IP, E
Bio Background	The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Bio References	Mutational analysis of death receptor genes Fas, TRAILR1 and TRAILR2 in prostate carcinomas. Park SW, et al. APMIS, 2010 Aug. PMID 20666744.Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. Frese-Schaper M, et al. FEBS Lett, 2010 Jul 2. PMID 20450916.TRAIL-induced apoptosis and expression of death receptor TRAIL-R1 and TRAIL-R2 in bladder cancer cells. Szliszka E, et al. Folia Histochem Cytobiol, 2009. PMID 20430723.
Clonality	Monoclonal
Gene ID	8795
Gene Name	TNFRSF10B
Subtitle	Mouse monoclonal antibody raised against a partial recombinant TNFRSF10B.
Reactivity	H
Legend image 1	Immunoprecipitation of TNFRSF10B transfected lysate using anti-TNFRSF10B monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TNFRSF10B MaxPab rabbit polyclonal antibody.
Type image 1	IP
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Detection limit for recombinant GST tagged TNFRSF10B is approximately 1ng/ml as a capture antibody.
Type image 3	E
Other Accession	BC001281
Isotype	IgG1 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	TNFRSF10B (AAH01281, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_003833.4; NP_671716.2
	Clone: 2D6
Org Accession	AAH01281
Gene Description	tumor necrosis factor receptor superfamily, member 10b
Gene Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq

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