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TREM1 Antibody (monoclonal) (M01)

TREM1 Antibody (monoclonal) (M01)

ArtNr	ABC-AT4336a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, ELISA
Clon	3F5
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TREM1, Triggering receptor expressed on myeloid cells 1, Triggering receptor expressed on monocytes 1, TREM-1, CD354
Lieferbar
Primary Accession	Q9NP99
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).
Bio References	Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Signaling pathways of the TREM-1- and TLR4-mediated neutrophil oxidative burst. Haselmayer P, et al. J Innate Immun, 2009 Oct. PMID 20375613.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis: association with severity of pulmonary fibrosis. Tomita H, et al. J Rheumatol, 2010 Apr. PMID 20156945.Serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and pentraxin 3 (PTX3) as markers of infection in febrile patients with systemic lupus erythematosus. Kim J, et al. Clin Exp Rheumatol, 2009 Sep-Oct. PMID 19917159.
Clonality	Monoclonal
Gene ID	54210
Gene Name	TREM1
Subtitle	Mouse monoclonal antibody raised against a full length recombinant TREM1.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (49.28 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Detection limit for recombinant GST tagged TREM1 is approximately 0.1ng/ml as a capture antibody.
Type image 2	E
Other Accession	BC017773
Isotype	IgG2b Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	TREM1 (AAH17773.1, 21 a.a. ~ 234 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001229518.1; NP_001229519.1; NP_061113.1
	Clone: 3F5
Org Accession	AAH17773.1
Gene Description	triggering receptor expressed on myeloid cells 1
Gene Summary	Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM

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ABC-AT4336a-datasheet.pdf

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Menge: 100 ug

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