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ZW10 Antibody (monoclonal) (M05)

ZW10 Antibody (monoclonal) (M05)

ArtNr	ABC-AT4649a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, ELISA
Clon	200000
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ZW10, Centromere/kinetochore protein zw10 homolog
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Primary Accession	O43264
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.
Bio References	Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. Chan YW, et al. J Cell Biol, 2009 Jun 1. PMID 19468067.Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport. Aoki T, et al. Mol Biol Cell, 2009 Jun. PMID 19369418.N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function. Inoue M, et al. Genes Cells, 2008 Aug. PMID 18782227.Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. Famulski JK, et al. J Cell Biol, 2008 Feb 11. PMID 18268100.Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. Famulski JK, et al. Curr Biol, 2007 Dec 18. PMID 18065224.
Clonality	Monoclonal
Gene ID	9183
Gene Name	ZW10
Subtitle	Mouse monoclonal antibody raised against a partial recombinant ZW10.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Western Blot analysis of ZW10 expression in transfected 293T cell line by ZW10 monoclonal antibody (M05), clone 2E5. Lane 1: ZW10 transfected lysate(88.8 KDa). Lane 2: Non-transfected lysate.
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western blot analysis of ZW10 over-expressed 293 cell line, cotransfected with ZW10 Validated Chimera RNAi ( (Cat # AT4649a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Detection limit for recombinant GST tagged ZW10 is approximately 0.1ng/ml as a capture antibody.
Type image 4	E
Other Accession	NM_004724
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	ZW10 (NP_004715, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_004715.1
	Clone: 200000
Org Accession	NP_004715
Gene Description	ZW10, kinetochore associated, homolog (Drosophila)
Gene Summary	This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. [provided by RefSeq

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Menge: 100 ug

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