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Guinea pig Anti-Pan NaV Antibody

Guinea pig Anti-Pan NaV Antibody

ArtNr	ALO-ASC-003-GP-25ul
Hersteller	Alomone
Menge	25 ul
Quantity options	0.2 ml 25 ul 50 ul
Kategorie	Metabolism Diabetes Antibodies Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Lyophilized
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Cavia
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	Affinity purified on immobilized antigen.
Formula	PBS pH7.4, 1% BSA with 0.05% sodium azide
Sequence	TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat NaV1.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Polyclonal
Manufacturer - Type	Antibodies
Manufacturer - Category	Antibodies
Manufacturer - Targets	Pan sodium channel, SP19
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Manufacturer - Format	Lyophilized powder
Short description	A Guinea Pig Polyclonal Antibody to Pan NaV channels
Description	Pan sodium channel, SP19 - A Guinea Pig Polyclonal Antibody to Pan NaV Channel
Clonality	Polyclonal
Homology	The epitope is identical in all isoforms of NaV1 in all vertebrates, and highly homologous in molluscan and insect voltage-gated Na+ channels
Standard quality control of each lot	Western blot analysis
Peptide confirmation	Confirmed by amino acid analysis and mass spectrometry
Reconstitution	25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody Concentration After Reconstitution	1 mg/ml
Preservative	1% BSA, 0.05% NaN3
Immunogen Location	Intracellular loop between domains III and IV
Specificity	SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A, SCN10A, SCN11A
Immunogen source species	Rat
PH	7, 4
UNSPSC	41116161
Antigen Preadsorption Control	1 µg peptide per 1 µg antibody
Scientific Background	Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6, 7

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