Anti-TGF beta Receptor III/TGFBR3 Antibody Picoband®

Primary Antibodies

At -20°C for one year from date of receipt.
After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.
Avoid repeated freezing and thawing.

12252 MW

Western blot, 0.25-0.5 ?g/ml, Human

Flow Cytometry (Fixed), 1-3 ?g/1x10⁶ cells, Human

ELISA, 0.1-0.5 ?g/ml, -

CD3e molecule

E.coli-derived human TGF beta Receptor III/TGFBR3 recombinant protein (Position: H37-R649).

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:19956738, PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.

Boster Bio Anti-TGF beta Receptor III/TGFBR3 Antibody Picoband® catalog # A02765-5. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.