Anti-SARS-CoV-2 ORF3a Antibody

Rabbit IgG

140 kDa, 130 kDa, 110 kDa

Polyclonal

3a

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF3a encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF3a protein is thought to be a protein with ion channel activity (viroporin) that activates the NLRP3 inflammasome. ORF3a may also play a role in virus replication and pathogenesis.

Each vial contains 4 mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Cytoplasm.

Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.