PARP2 Antibody

PARP2

ADP ribosyltransferase like 2 antibody; ADP-ribosyltransferase diphtheria toxin-like 2 antibody; ADPRT 2 antibody; ADPRT-2 antibody; ADPRT2 antibody; ADPRTL 2 antibody; ADPRTL 3 antibody; ADPRTL2 antibody; ADPRTL3 antibody; ARTD2 antibody; hPARP 2 antibody; hPARP-2 antibody; hPARP2 antibody; NAD(+) ADP ribosyltransferase 2 antibody; NAD(+) ADP-ribosyltransferase 2 antibody; pADPRT 2 antibody; pADPRT-2 antibody; pADPRT2 antibody; PARP 2 antibody; PARP-2 antibody; PARP2 antibody; PARP2_HUMAN antibody; Poly (ADP ribose) polymerase family member 2 antibody; Poly (ADP ribosyl) transferase like 2 antibody; poly (ADP-ribose) polymerase 2 antibody; Poly [ADP ribose] synthetase 2 antibody; Poly [ADP-ribose] polymerase 2 antibody; Poly(ADP ribose) synthetase antibody; Poly[ADP-ribose] synthase 2 antibody

Synthesized peptide derived from internal of human PARP2.

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Sugano S., Nat. Genet. 36:40-45(2004).
de Murcia G.M., J. Biol. Chem. 277:23028-23036(2002).
Bennett K.L., Submitted (OCT-2008).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from internal of Human PARP2.