SEMA5A Antibody

Polyclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Recombinant Human Semaphorin-5A protein (201-400AA)

Bifunctional axonal guidance cue regulated by sulfated proteoglycans, attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

>95%, Protein G purified

Human

Polyclonal