PRKAB1 antibody

ArtNr	FNab00377-100ug
Hersteller	FineTest
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1,AMPKb),PRKAB1,AMPK
Lieferbar
Manufacturer - Targets	PRKAB1
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Background	The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Clonality	polyclonal
Immunogen	protein kinase, AMP-activated, beta 1 non-catalytic subunit
Observed MW	37 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Manufacturer - Research Area	Cardiovascular, Metabolism, Signal Transduction

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