APOBEC3G antibody

ArtNr	FNab00495-100ug
Hersteller	FineTest
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	DNA dC->dU-editing enzyme APOBEC-3G,APOBEC-related cytidine deaminase (APOBEC-related protein,ARCD),APOBEC-related protein 9 (ARP-9),CEM-15 (CEM15),Deoxycytidine deaminase (A3G),APOBEC3G
Lieferbar
Manufacturer - Targets	APOBEC3G
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses(SIVs), hepatitis B virus(HBV), equine infectious anemia virus(EIAV), xenotropic MuLV-related virus(XMRV) and simian foamy virus(SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Clonality	polyclonal
Immunogen	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Observed MW	46 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Manufacturer - Research Area	Epigenetics, Immunology, Metabolism

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