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BRD8 antibody

BRD8 antibody

ArtNr	FNab00950-100ug
Hersteller	FineTest
Menge	100 ug
Quantity options	100 ug 100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Clon	4B2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Bromodomain-containing protein 8,Skeletal muscle abundant protein,Skeletal muscle abundant protein 2,Thyroid hormone receptor coactivating protein of 120 kDa (TrCP120),p120,BRD8,SMAP,SMAP2
Lieferbar
Manufacturer - Targets	BRD8
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Clonality	monoclonal
Immunogen	bromodomain containing 8
Observed MW	120 kDa
Purification	Protein A+G purification
Recommended dilution	WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Manufacturer - Research Area	Signal Transduction, Metabolism

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