DTX3L antibody

ArtNr	FNab02556-100ug
Hersteller	FineTest
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	E3 ubiquitin-protein ligase DTX3L,B-lymphoma- and BAL-associated protein,Protein deltex-3-like,RING-type E3 ubiquitin transferase DTX3L,Rhysin-2 (Rhysin2),DTX3L,BBAP
Lieferbar
Manufacturer - Targets	DTX3L
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4(H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation(H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Clonality	polyclonal
Immunogen	deltex 3-like(Drosophila)
Observed MW	84 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:2000
Manufacturer - Research Area	Epigenetics, Signal Transduction, Metabolism, Developmental biology

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