IFIH1 antibody

ArtNr	FNab04134-100ug
Hersteller	FineTest
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IP, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Interferon-induced helicase C domain-containing protein 1,Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen),Helicase with 2 CARD domains (Helicard),Interferon-induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5 (MDA-5),Murabutide down-regulated protein,RIG-I-like receptor 2 (RLR-2),RNA helicase-DEAD box protein 116,IFIH1,MDA5,RH116
Lieferbar
Manufacturer - Targets	IFIH1
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA(>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein(MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons(IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus(EMCV) and mengo encephalomyocarditis virus(ENMG). Can also detect other viruses such as dengue virus(DENV), west Nile virus(WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L(RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
Clonality	polyclonal
Immunogen	interferon induced with helicase C domain 1
Observed MW	117-125 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:2000; IP: 1:200-1:2000
Manufacturer - Research Area	Immunology, Metabolism
Manufacturer - Synonym	Interferon-induced helicase C domain-containing protein 1, Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen), Helicase with 2 CARD domains (Helicard), Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5 (MDA-5), Murabutide down-regulated protein, RIG-I-like receptor 2 (RLR-2), RNA helicase-DEAD box protein 116, IFIH1, MDA5, RH116

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