Anti-Mouse CD126 In Vivo Antibody - Low Endotoxin (15A7)

IL6R

Aggregation level <= 5%

Activated T and B cells, monocytes, hepatocytes, plasma cells

CD126 is an 80 kD IL-6 receptor alpha chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor beta chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The beta chain does not bind IL-6 by itself, but associates with the alpha-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation.

<= 1.0 EU/mg as determined by the LAL method

Products are for research use only. Not for use in diagnostic or therapeutic procedures.