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Anti-Mouse CD126 In Vivo Antibody - Low Endotoxin (15A7)

Anti-Mouse CD126 In Vivo Antibody - Low Endotoxin (15A7)

Item no.	ICH1104-0.5MG
Manufacturer	IchorBio
Amount	0.5 mg
Quantity options	0.5 mg 1 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies In Vivo Antibodies By Cell Type Carcinoma Obesity Western Blot
Type	Antibody
Applications	WB
Clone	15A7
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b Kappa
Purity	>95% by SDS-PAGE and HPLC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	in vivo
Available
Specificity	Anti-CD126 In Vivo Antibody - Low Endotoxin (15A7) recognizes an epitope on Mouse CD126. The D7715A7 (Clone 15A7) antibody blocks IL-6/IL-6 receptor interactions
Manufacturer - Type	Low Endotoxin, anti-mouse
Manufacturer - Targets	IL6R
Storage Conditions	anti-CD126 In Vivo Antibody - Low Endotoxin (15A7) is stable when stored at 2-8C. For long term storage aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.
Aggregation	Aggregation level <= 5%
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Antigen Distribution	Activated T and B cells, monocytes, hepatocytes, plasma cells
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Background	CD126 is an 80 kD IL-6 receptor alpha chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor beta chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The beta chain does not bind IL-6 by itself, but associates with the alpha-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	<= 1.0 EU/mg as determined by the LAL method
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Immunogen	OKT4 hybridoma cells

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 mg

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Delivery expected until 9/4/2025

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