« Zurück
Home /
Anti-Mouse PD-1 In Vivo Antibody - Low Endotoxin (RMP1-14)

Anti-Mouse PD-1 In Vivo Antibody - Low Endotoxin (RMP1-14)

Hersteller	IchorBio
Kategorie	Oncology Antibodies In Vivo Antibodies By Cell Type Carcinoma Hematology Lymphoma Myelofibrosis Western Blot Blocking
Typ	Antibody
Specific against	Mouse
Clon	RMP1-14
Isotype	IgG2a Kappa
Applikationen	WB, Blocking
Menge	1mg
Host	Rat
ArtNr	ICH1132-1MG
Targets	CD279
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Aggregation	Aggregation level <= 5%
Antigen Distribution	Subset of double negative thymocytes, activated T and B cells
Application Notes	Blocking: Clone RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1. For immune checkpoint antibodies 200 ug per mouse per injection is the standard dosage in the literature. For this anti-PD-1 (clone RMP1-14), we suggest to inject 200 ug/mouse ip generally on days 3, 6 and 9, post injection of tumor. Sometime up to six injections depending on the length of the experiment may be required. Each investigator should determine their own optimal working dilution for specific applications.
Background	CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	<= 1.0 EU/mg as determined by the LAL method
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Immunogen	Mouse PD-1 transfected BHK cells
Product Type	Low Endotoxin, anti-mouse
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Storage	anti-PD-1 In Vivo Antibody - Low Endotoxin (RMP1-14) is stable when stored at 2-8C. For longer term storage (> 3 months) it is recommended to store this antibody at -70oC.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 1mg

lieferbar

Lieferung vsl. bis 06.06.2024

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail

Angebot anfordern