Anti-Human/Mouse BACE-1 Ectodomain - 500 µg

CyTOF®, FC, IHC FFPE, WB

BACE-1

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BACE-1 is an aspartic protease and an integral membrane protein. BACE-1 is the peptidase predominantly responsible for cleavage of the amyloid precursor protein β site in the brain to generate the amyloid β peptide. Because the amyloid β peptide is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. BACE-1 is expressed in a variety of human tissues. It is likely that this peptidase has functions in addition to its hydrolysis of the amyloid precursor protein. The peptidase activity of BACE-1 is optimal under mildly acidic conditions (pH 3.5 -5.5), consistent with its proposed function in an acidic intracellular compartment.

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 8 µg/ml. The recommended secondary antibody for IHC is PN:M114. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Mouse Anti-Human Beta-Site APP Cleaving Enzyme 1 (BACE-1) (Clone 137612) recognizes an epitope on Human BACE-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. No cross-reactivity was observed with rhBACE-2, rmBACE-2, rhADAM8, rmADAM9, rmADAM10, rhADAM15, or rhTACE.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

NS0-Derived Recombinant Human BACE-1 Ectodomain

Monoclonal Antibody, Beta-Site APP Cleaving Enzyme 1, 137612, BACE-1, Human, Anti-Human/Mouse BACE-1 Ectodomain, APP beta-secretase, ASP2, Aspartyl protease 2, BACE1, BACE-1, BACEAsp 2, beta-secretase 1 precursor variant 1, beta-secretase 1, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme 1, beta-site APP-cleaving enzyme, EC 3.4.23, EC 3.4.23.46, FLJ90568, HSPC104, KIAA1149, memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2