Anti-Human IL-1 RII (Clone 32437) - 25 µg

ICC, N, WB

IL-1 sRII

Next Day Ambient

Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects.1 IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods.2 IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.3

Neutralization: This antibody is useful for neutralization of Human IL-1 RII bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-1 RII (at 2 ng/ml) is 2-6 µg/ml.
Immunocytochemistry: Suitable for use at concentration of 8-25 µg/mL.

Mouse Anti-Human interleukin 1 soluble receptor type II (IL-1 RII) (Clone 32437) recognizes an epitope on Human IL-1 RII. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows no cross-reactivity with rhIL-1 RI, rhIL-18 R and rmIL-18 R.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human IL-1 RII (> 98%)

Monoclonal Antibody, Interleukin-1 Soluble Receptor Type II, IL1R2, CD121b, IL1RB, MGC47725, 32437, IL-1 sRII, Human, Anti-Human IL-1 RII, beta, CD121b antigen, CD121b, IL-1 R beta, IL-1 RII, IL1R2, IL1RBCD121 antigen-like family member B; IL-1R-beta; IL1RII, IL-1RII, IL-1RT2, IL-1RT-2, interleukin 1 receptor, type II, Interleukin-1 receptor beta