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Anti-Human IL-1 RII (Clone 32437) - 25 µg

Anti-Human IL-1 RII (Clone 32437) - 25 µg

Item no.	LEIN-I-640-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	25 ug 500 ug
Category	Antibodies Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Monoclonal
Applications	WB, ICC
Clone	32437
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Akoum, A. et al. (2005) Hum Rep. 20: 1177 2. Akoum, A. et al. (2001) Biol Rep. 65: 890 3. Liu, J. et al. (2008) Fertil Steril. 89: 42
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ICC, N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	IL-1 sRII
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects.1 IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods.2 IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.3
Background	Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects.¹ IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods.² IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.³
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human IL-1 RII bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-1 RII (at 2 ng/ml) is 2-6 µg/ml. Immunocytochemistry: Suitable for use at concentration of 8-25 µg/mL.
PubMed	IL-1 sRII
Manufacturer - Specificity	Mouse Anti-Human interleukin 1 soluble receptor type II (IL-1 RII) (Clone 32437) recognizes an epitope on Human IL-1 RII. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows no cross-reactivity with rhIL-1 RI, rhIL-18 R and rmIL-18 R.
RRID	AB_2830762
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human IL-1 RII (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interleukin-1 Soluble Receptor Type II, IL1R2, CD121b, IL1RB, MGC47725, 32437, IL-1 sRII, Human, Anti-Human IL-1 RII, beta, CD121b antigen, CD121b, IL-1 R beta, IL-1 RII, IL1R2, IL1RBCD121 antigen-like family member B; IL-1R-beta; IL1RII, IL-1RII, IL-1RT2, IL-1RT-2, interleukin 1 receptor, type II, Interleukin-1 receptor beta

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-640-25ug-safety-datasheet.pdf