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Anti-Mouse IL-21 - 100 µg

Anti-Mouse IL-21 - 100 µg

ArtNr	LEIN-I-728-100ug
Hersteller	Leinco Technologies
Menge	100 ug
Quantity options	100 ug 25 ug
Kategorie	Antibodies Western Blot ELISA Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry
Typ	Antibody Primary
Applikationen	WB, ICC, ELISA
Specific against	Mouse (Murine, Mus musculus)
Host	Caprine
Citations	1. Foster, D. et al. (2000) Nature 408: 57 2. Clegg, CH. et al. (2002) J. Leukoc. Biol. 72: 856 3. Leonard, WJ.et al. (2002) Science 298: 1630 4. Joannopoulos, K.et al. (2003) J. Immunol. 171: 608 5. Lipsky, PE. et al. (2008) Ann Rheum. Dis. 3: 83
NCBI	60505
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	ELISA Cap, ICC, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	IL-21
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.1, 2 This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-153 and is a key factor in the transition between innate and adaptive immune responses.4 The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.5
Background	Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.^{1, 2} This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-15³ and is a key factor in the transition between innate and adaptive immune responses.⁴ The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.⁵
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Mouse IL-21 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse IL-21 (at 250 ng/ml) is 1 - 15 µg/ml. Immunocytochemistry: This antibody will detect IL-21 in cells. The working dilution is 5 - 15 μg/mL.
PubMed	IL-21
Manufacturer - Specificity	Goat Anti-Mouse Interleukin 21 (IL-21) recognizes Mouse IL-21. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830849
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	E. coli-Derived Mouse Interleukin-21
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Interleukin-21, Za11, IL-21, Mouse IL-21, Anti-Mouse IL-21, IL21, IL-21, IL-21Za11interleukin-21, interleukin 21, interleukin-21 isoform

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