GFR alpha 1 Antibody

blue ice or room temperature

51 kDa

GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα -1 recently. GFRα -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

GFR alpha 1 Antibody is Antibody is DEAE purified.

PRS-1304-0.1mg

PRS-1306-0.1mg

1 mg/ml

GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1.

The immunogen is located within amino acids 360 - 410 of GFR alpha 1.

GDNF family receptor alpha 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.