GFR alpha 1 Antibody

Blue Ice

51 kDa

GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα -1 recently. GFRα -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Trial Size

20141405

PRS-1303-0.1mg

PRS-1305-0.1mg

PRS-10-301-4um

GFR alpha 1 Antibody is supplied in PBS containing 0.02% sodium azide.

GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.