GCK Antibody

WB: 1:200 - 1:1000

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

Store at -20°C. Avoid freeze / thaw cycles.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Polyclonal

Homo sapiens